A Symposium about Syngap1 and Related Disorders

The Syngap1 Symposium 2021 brings together exceptional scientists from around the world with the incentive to advance Syngap1 research, build networks, stimulate collaboration and coordinate efforts. 

15 – 16
MAR 2021

Due to the Covid 19 pandemic, this year’s symposium will take place over the internet.

What is Syngap1?

Syngap1 is a protein that is critical for the development of cognition and proper synapse function. Mutations in the Syngap1 gene lead to a rare neurodevelopmental disorder. Currently, about 400 children are diagnosed world-wide with this disease. Mutations in Syngap1 are associated with intellectual disability and are proposed to play a significant role in other diseases such as epilepsy, autism spectrum disorders and schizophrenias. 

Our Mission

The non-profit organization Leon&friends e.V. is the main organizer of the Syngap1 Symposium and wants to inform the public and the scientific community about the disease and the current, high-class ongoing research. The idea is to bring together  scientists to inform about recent developments in the research field, exchange ideas and present cutting-edge technologies that can be used for research on Syngap1.

About the Event

The Syngap1 Symposium 2021 will take place from March 15th to 16th. Due to the current pandemic, we’ve decided that this year’s event will take place online. The event’s public sessions can be attended free-of-charge (email registration required). Check out the schedule for a detailed overview on lectures and topics. 

Tentative List of Speakers (under reservation)

Gavin Rumbaugh
Florida, USA

Simon Hippenmeyer
Klosterneuburg, AT

Àlex Bayés
Barcelona, ESP

Vanja Nagy
Vienna, AT

Gaia Novarino
Klosterneuburg, AT

Frank Edenhofer
Innsbruck, AT

Michael Courtney
Turku, FIN

James Premdoss Clement
Bangalore, IND

Noboru Komiyama
Edinburgh, UK

Matthias Jung
Halle, GER

Mimoun Azzouz
Sheffield, UK

Rupert Lanzenberger
Vienna, AT

Tentative Schedule (under reservation)

Unless stated otherwise, the lectures can be recorded.

  • Monday, 15th March
  • Tuesday, 16th March

13:45 - 14:00

Welcome words / Introduction Leon & Friends – Sandra Apler

14:00 - 14:45

Keynote lecture 1: Gaia Novarino, Klosterneuburg, Austria: "Convergent molecular pathways in neurodevelopment disorders"

15:00 - 15:30

Vanja Nagy, Vienna, Austria: “Modeling intellectual disabilities in a dish: characterizing genetic pathophysiology in cell lines and primary cell cultures”

15:030 - 16:00

Michael Courtney, Turku, Finland: “Monitoring and manipulating plasticity-regulating neuronal signaling networks“

16:00 - 16:30

Matthias Jung, Halle, Germany: “Modelling common pathways of Syngap1 syndrome and schizophrenia in human iPS cells.” [recording only partly allowed]

16:30 - 17:00


17:00 - 18:00

Keynote lecture 2: Gavin Rumbaugh, Scripps, FL, USA: “Syngap1 Disorders: How This Gene Regulates Brain Function and Strategies to Fix It When Broken"

18:00 - 18:30

Mimoun Azzouz, Sheffield, United Kingdom: „Prospects for gene therapeutics in neurological disorders“

18:30 - 19:00

Frank Edenhofer, Innsbruck, Austria: „Taking the short cut: induced neural stem cells in disease modeling and cell therapy"


9:00 - 9:30


9:30 - 10:00

Simon Hippenmeyer, Klosterneuburg, Austria: “Genetic Dissection of Neural Development in Health and Disease using Mosaic Analysis with Double Markers (MADM)”

10:00 - 10:30

Noboru H. Komiyama, Edinburgh, UK: tba

10:30 - 11:00

James P. Clement, Bangalore, India: “Pharmacological restoration of chloride cotransporter rescues physiological and functional deficits in Syngap1+/- “

11:00 - 11:30


11:30 - 13:00

Lunch Break

13:00 - 13:30

Alex Bayés, Barcelona, Spain : “A systems biology approach to elucidate the postsynaptic molecular alterations resulting from Syngap1 Deficiency“

13:30 - 15:30

Short talks, tba

15:30 - 16:00

Maria Isabel Carreno Munoz, Montreal Quebec; "Sensory brain responses alterations as translational biomarkers for SYNGAP1 haploinsufficiency"

16:00 - 16:30


16:30 - 17:00

Prof. Kluger Team

17:00 - 17:45

Keynote lecture 3: Rick Hughanir, "Twenty years of SynGAP research: from Synapses to Cognition"

18:00 - 20:00

Researchers Session –Discussion about talks and future of SYNGAP research 


Public Sessions

Free entry

Attendance to all public sessions is free-of-charge, but please send an email to hallo@leonandfriends.org or use the form below until 1st March 2021, with contact information and the attendance reason (e.g. pure scientific interest OR work in the field XY), important for us to know more about the audience, to plan coffee breaks etc.

Closed Sessions

Email registration

Extra registration e-mail necessary to hallo@leonandfriends.org or by using the form below until 1st March 2021, with contact information and the attendance reason, because of confidentiality reasons.

Abstract Submission

for short oral presentation

Email to hallo@leonandfriends.org or use the form below until 1st March 2021, with a short abstract of maximum one page structured in authors + affiliation, contact data, introduction, material & methods, results and conclusion, font format etc. are free to choose.

Registration Form


Leon & Friends e.V.
The non-profit organization aims to support children who suffer from Syngap1 syndrome and to drive research for treatment methods.
Visit website I Donate here


AIT Austrian Institute of Technology
The AIT is Austria’s largest Research and Technology Organization (RTO), employing about 1,300 people.
Visit website

ANA Austrian Neuroscience Association
ANA provides a platform for Austrian Neuroscience  and is amember of the Federation of European Neuroscience Societies (FENS).
Visit website

The CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences is an interdisciplinary research institute committed to advancing the understanding of human diseases through basic and biomedical research.
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The Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases
The LBI-RUD has been founded to implement a coordinated research program on the genetic and functional basis of rare diseases.
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Winfried Neuhaus
AIT – Austrian Institute of Technology, Vienna

Sigismund Huck
Center for Brain Research, Vienna

Vanja Nagy
LBI Rare and Undiagnosed Diseases & CeMM, Vienna

© 2020 Leon & Friends e.V. I Website by Philipp Apler