A Symposium about Syngap1 and Related Disorders

The Syngap1 Symposium 2021 brings together exceptional scientists from around the world with the incentive to advance Syngap1 research, build networks, stimulate collaboration and coordinate efforts. 

15 – 16
MAR 2021

Due to the Covid 19 pandemic, this year’s symposium will take place over the internet.

What is Syngap1?

Syngap1 is a protein that is critical for the development of cognition and proper synapse function. Mutations in the Syngap1 gene lead to a rare neurodevelopmental disorder. Currently, about 400 children are diagnosed world-wide with this disease. Mutations in Syngap1 are associated with intellectual disability and are proposed to play a significant role in other diseases such as epilepsy, autism spectrum disorders and schizophrenias. 

Our Mission

The non-profit organization Leon&friends e.V. is the main organizer of the Syngap1 Symposium and wants to inform the public and the scientific community about the disease and the current, high-class ongoing research. The idea is to bring together  scientists to inform about recent developments in the research field, exchange ideas and present cutting-edge technologies that can be used for research on Syngap1.

About the Event

The Syngap1 Symposium 2021 will take place from March 15th to 16th. Due to the current pandemic, we’ve decided that this year’s event will take place online. The event’s public sessions can be attended free-of-charge (email registration required). Check out the schedule for a detailed overview on lectures and topics. 

Tentative List of Speakers

Gavin Rumbaugh
Florida, USA

Simon Hippenmeyer
Klosterneuburg, AT

Àlex Bayés
Barcelona, ESP

Vanja Nagy
Vienna, AT

Gaia Novarino
Klosterneuburg, AT

Frank Edenhofer
Innsbruck, AT

Michael Courtney
Turku, FIN

James Premdoss Clement
Bangalore, IND

Noboru Komiyama
Edinburgh, UK

Matthias Jung
Halle, GER

Mimoun Azzouz
Sheffield, UK

Richard Huganir
Baltimore, USA

Gerhard Kluger
Vogtareuth, GER

Maria Isabel Carreño Muñoz
Montreal, CA

Eric Hosy
Bordeaux, FR

Tentative Schedule

  • Monday, 15th March
  • Tuesday, 16th March

13:45 - 14:00

Welcome words / Introduction Leon & Friends – Sandra Apler

14:00 - 14:45

Keynote lecture 1: Gaia Novarino, Klosterneuburg, Austria: "Convergent molecular pathways in neurodevelopment disorders"

15:00 - 15:30

Vanja Nagy, Vienna, Austria: “Modeling intellectual disabilities in a dish: characterizing genetic pathophysiology in cell lines and primary cell cultures”

15:30 - 15:35


15:35 - 16:05

Michael Courtney, Turku, Finland: “Monitoring and manipulating plasticity-regulating neuronal signaling networks“

16:05 - 16:35

Matthias Jung, Halle, Germany: “Modelling common pathways of Syngap1 syndrome and schizophrenia in human iPS cells.”

16:35 - 16:55

Discussion of preceding talks

16:55 - 17:00


17:00 - 18:00

Keynote lecture 2: Gavin Rumbaugh, Scripps, FL, USA: “Syngap1 Disorders: How This Gene Regulates Brain Function and Strategies to Fix It When Broken"

18:00 - 18:30

Mimoun Azzouz, Sheffield, United Kingdom: „Prospects for gene therapeutics in neurological disorders“

18:30 - 19:00

Frank Edenhofer, Innsbruck, Austria: „Taking the short cut: induced neural stem cells in disease modeling and cell therapy"

19:00 - 19:30

Discussion of preceding talks


9:00 - 9:30

Alex Bayés, Barcelona, Spain : “A systems biology approach to elucidate the postsynaptic molecular alterations resulting from Syngap1 Deficiency“

9:30 - 10:00

Simon Hippenmeyer, Klosterneuburg, Austria: “Genetic Dissection of Neural Development in Health and Disease using Mosaic Analysis with Double Markers (MADM)”

10:00 - 10:30

Noboru H. Komiyama, Edinburgh, UK: "SynGAP1 in NMDA receptor complex: Implications for development of therapeutic strategies for ASD."

10:30 - 10:40


10:40 - 11:10

James P. Clement, Bangalore, India: “Pharmacological restoration of chloride cotransporter rescues physiological and functional deficits in Syngap1+/- “

11:10 - 11:40

Eric Hosy, France: "Why organization of synaptic proteins at the nanoscale is essential for synaptic physiology?"

11:40 - 12:00

Discussion of preceding talks

12:00 - 13:00

Lunch Break

13:00 - 14:50

Short talks

14:50 - 15:00


15:00 - 15:30


15:30 - 16:00

Maria Isabel Carreno Munoz, Montreal Quebec; "Sensory brain responses alterations as translational biomarkers for SYNGAP1 haploinsufficiency"

16:00 - 16:30

Prof. Kluger & Team: „Clinical aspects in SYNGAP1 and invitation for collaboration: project PATRE“

16:30 - 16:55

Discussion of preceding talks

16:55 - 17:00


17:00 - 18:00

Keynote lecture 3: Richard Huganir: "Twenty years of SynGAP research: from Synapses to Cognition"

18:00 - 20:00

Discussion on Gaps in Syngap research


Attendance to all lectures and sessions is free-of-charge, but restricted. Please send your registration to hallo@leonandfriends.org or use the form below until March 8th, 2021 with contact information and your attendance reason (e.g. pure scientific interest OR work in the field XY). You will receive an invitation link shortly before the event.

Registration Form


Leon & Friends e.V.
The non-profit organization aims to support children who suffer from Syngap1 syndrome and to drive research for treatment methods.
Visit website I Donate here


AIT Austrian Institute of Technology
The AIT is Austria’s largest Research and Technology Organization (RTO), employing about 1,300 people.
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ANA Austrian Neuroscience Association
ANA provides a platform for Austrian Neuroscience  and is amember of the Federation of European Neuroscience Societies (FENS).
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The CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences is an interdisciplinary research institute committed to advancing the understanding of human diseases through basic and biomedical research.
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The Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases
The LBI-RUD has been founded to implement a coordinated research program on the genetic and functional basis of rare diseases.
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Winfried Neuhaus
AIT – Austrian Institute of Technology, Vienna

Sigismund Huck
Center for Brain Research, Vienna

Vanja Nagy
LBI Rare and Undiagnosed Diseases & CeMM, Vienna

© 2020 Leon & Friends e.V. I Website by Philipp Apler