A Symposium about Syngap1 and Related Disorders

The Syngap1 Symposium 2020 brings together exceptional scientists from around the world with the incentive to advance Syngap1 research, build networks, stimulate collaboration and coordinate efforts. 

Event
postponed

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences

What is Syngap1?

Syngap1 is a protein that is critical for the development of cognition and proper synapse function. Mutations in the Syngap1 gene lead to a rare neurodevelopmental disorder. Currently, about 400 children are diagnosed world-wide with this disease. Mutations in Syngap1 are associated with intellectual disability and are proposed to play a significant role in other diseases such as epilepsy, autism spectrum disorders and schizophrenias. 

Our Mission

The non-profit organization Leon&friends e.V. is the main organizer of the Syngap1 Symposium and wants to inform the public and the scientific community about the disease and the current, high-class ongoing research. The idea is to bring together  scientists to inform about recent developments in the research field, exchange ideas and present cutting-edge technologies that can be used for research on Syngap1.

About the Event

The Syngap1 Symposium 2020 will take place from March 23rd to 24th in the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences on the 8th floor seminar room. The event’s public sessions can be attended free-of-charge (email registration required). Check out the schedule for a detailed overview on lectures and topics. Another part of the symposium is the Syngap1 Project Award endowed with 5,000 Euro.

Syngap1 5000 € Project Award

Leon & friends e.V. would like to support and grant research project ideas from students (MSc, PhDs as well) with 5,000 € per project. These projects will be awarded at the symposium. The proposed project should be explained including hypothesis, relevant literature, methodical approach and availability / feasibility on maximum 2 pages and sent to winfried.neuhaus@ait.ac.at until 13th March 2020.

Tentative List of Speakers

Gavin Rumbaugh
Florida, USA

Simon Hippenmeyer
Klosterneuburg, AT

Àlex Bayés
Barcelona, ESP

Vanja Nagy
Vienna, AT

Gaia Novarino
Klosterneuburg, AT

Frank Edenhofer
Innsbruck, AT

Michael Courtney
Turku, FIN

James Premdoss Clement
Bangalore, IND

Noboru Komiyama
Edinburgh, UK

Matthias Jung
Halle, GER

Mimoun Azzouz
Sheffield, UK

Rupert Lanzenberger
Vienna, AT

Tentative Schedule

  • Monday, 23rd March
  • Tuesday, 24th March
Header

PUBLIC SESSION (free entry)

12:00

Registration and welcome reception

12:30

Welcome addresses

13:00 - 14:00

Keynote lecture: Gavin Rumbaugh, Scripps, FL, USA: “Syngap1 Disorders: How This Gene Regulates Brain Function and Strategies to Fix It When Broken”

14:00 - 14:30

Gaia Novarino, Klosterneuburg, Austria: "Convergent molecular pathways in neurodevelopment disorders"

14:30

Coffee break

15:00 - 15:30

Frank Edenhofer, Innsbruck, Austria: „Taking the short cut: induced neural stem cells in disease modeling and cell therapy“

15:30 - 16:00

Vanja Nagy, Vienna, Austria: “Modeling intellectual disabilities in a dish: characterizing genetic pathophysiology in cell lines and primary cell cultures”

16:00 - 16:30

Michael Courtney, Turku, Finland: “Monitoring and manipulating plasticity-regulating neuronal signaling networks“

16:30

Coffee break

17:00 - 17:30

Matthias Jung, Halle, Germany: “Modelling common pathways of Syngap1 syndrome and schizophrenia in human iPS cells.”

17:30 - 18:00

Mimoun Azzouz, Sheffield, United Kingdom: „Prospects for gene therapeutics in neurological disorders“

19:00

Dinner  (for invited speakers)

Header

CLOSED SESSION (extra registration necessary)

9:00

Coffee reception

9:30

Introduction of Technologies of Participants

10:15

Round table discussion – How to bring the field forward

11:15

Strategy discussions – How to get funding/Lobbying

13:00 - 14:00

Lunch break

PUBLIC SESSION (free entry)

14:00 - 14:30

Àlex Bayés, Barcelona, Spain : “A systems biology approach to elucidate the postsynaptic molecular alterations resulting from Syngap1 Deficiency“

14:30 - 15:00

Simon Hippenmeyer, Klosterneuburg, Austria: “Genetic Dissection of Neural Development in Health and Disease using Mosaic Analysis with Double Markers (MADM)”

15:00 - 15:30

Noboru H. Komiyama, Edinburgh, UK: “Investigation of therapeutic strategies for Syngap1 genetic mutation”

15:30

Coffee break

15:30 - 16:00

James P. Clement, Bangalore, India: “Pharmacological restoration of chloride cotransporter rescues physiological and functional deficits in Syngap1+/-“

16:30 - 17:00

Rupert Lanzenberger, Vienna, Austria: ”Molecular and functional neuroimaging in humans - new tools to investigate Syngap1 effects in vivo”

17:00 - 17:15

Oral short lecture 1

17:15 - 17:30

Oral short lecture 2

17:30 - 17:40

Farewell

Registration

Public Sessions

Free entry

Attendance to all public sessions is free-of-charge, but please send an email to winfried.neuhaus@ait.ac.at or use the form below until 13th March 2020, with contact information and the attendance reason (e.g. pure scientific interest OR work in the field XY), important for us to know more about the audience, to plan coffee breaks etc.

Closed Sessions

Email registration

Extra registration e-mail necessary to winfried.neuhaus@ait.ac.at or by using the form below until 13th March 2020, with contact information and the attendance reason, because of confidentiality reasons.

Abstract Submission

for short oral presentation

Email to winfried.neuhaus@ait.ac.at or use the form below until 13th March 2020, with a short abstract of maximum one page structured in authors + affiliation, contact data, introduction, material & methods, results and conclusion, font format etc. are free to choose.

Registration Form

Organizer

Leon & Friends e.V.
The non-profit organization aims to support children who suffer from Syngap1 syndrome and to drive research for treatment methods.
Visit website I Donate here

Co-Organizers

AIT Austrian Institute of Technology
The AIT is Austria’s largest Research and Technology Organization (RTO), employing about 1,300 people.
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ANA Austrian Neuroscience Association
ANA provides a platform for Austrian Neuroscience  and is amember of the Federation of European Neuroscience Societies (FENS).
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The CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences is an interdisciplinary research institute committed to advancing the understanding of human diseases through basic and biomedical research.
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The Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases
The LBI-RUD has been founded to implement a coordinated research program on the genetic and functional basis of rare diseases.
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Co-Chairs

Winfried Neuhaus
AIT – Austrian Institute of Technology, Vienna

Sigismund Huck
Center for Brain Research, Vienna

Vanja Nagy
LBI Rare and Undiagnosed Diseases & CeMM, Vienna

© 2020 Leon & Friends e.V. I Website by Philipp Apler